Obviously the first step would be to ensure you have a solid backup of the server as soon as possible. A worthwhile investment is Portlock Storage Manager. It's not expensive and is worth its weight in gold as it can image your entire server, as one would use Ghost to image a Windows PC.
The NSS verify and repair options are the best utilities for diagnosing and fixing problems with NSS pools/volumes, but utilities such as SpinRite are very useful for establishing if you do in fact have physical problems with the hard disc.
I'm sure I don't need to point out that a single disc environment is very bad news. I would always recommend an absolute minimum of RAID1 mirroring for a server whose data you consider valuable.