Hi David you have Symantic installed, which version please.
There is often reports and questions regarding 100% CPU usage and has been pinned down to Norton.
How big is your hard drive and how much space has been allocated for system restore? for Temp IE folders > internet cache
norton temp folders if it has one.
One of the main issues is with Office Excel has stopped working, if it has broken links
You can use your Office cd to run Diagnostics?
and clear temp files and reboot
How long since you ran a defragged on this hdd?
here's how to
http://www.kongtechnology.com/2008/04/26/how-to-defrag-windows-vista/here's quite an extensive list of help regarding Office excel
http://office.microsoft.com/en-au/excel/results.aspx?qu=office+excel+stopped+working&QueryID=ru8GYIbRj&av=ZXL110&sc=9&trc=100&stt=26