Check the IIS Manager and see if the correct certificate is installed on it.. If you have the new certificate with you use the following Exchange command to see if the certificate is currently enabled for IIS service
Get-ExchangeCertificate and copy and paste the Thumbprint of the new certificate, then run
Enable-ExchangeCertificate -Thumbprint -Services IIS
You can also try to disable SSL and check if OWA works without the HTTP(s), if it does not we'll concentrate on OWA not working and not SSL