It means that the Mail Transfer Agent timed out on the message. I'm guessing its on your end but can't be sure without further checking. the transaction time isn't too bad.
I'd turn on message tracking and check the event logs, if you could past that here along the domain you manage and some of the ones the error happens with
Any more information on the setup would be good also, firewall type, ISP, are you using a smarthost etc.