Hi,
To be honest the best bet is to use a SAN and have data replicating to a seperate partition. In this case then it is pretty easy to get exchange backup and running as a cluster only points to the partition so once you change the drive letter to the one that has failed the store will come back online.
I suggest you look at some offsite backup software/suppliers such as
www.keepitsafe.com as they can replicate the data for you using there software and you can recover will a very small amount of Down time.
Hope this helps!