1. It is NOT a Vista problem - rest assured.
2. Verify with your ISP that authentication is not required. Assuming not is not good enough.
3. Verify with your ISP that you have the correct SMTP for your setup. ISP's change SMTP's on unsuspecting customers.
4. Open Outlook -> Tools -> Accounts -> Next -> Select default account -> Change -> Test account settings. Record the results, especially error messages around the send.
5. While you are there, triple check each setting. A client paid me to come on site to troubleshoot an email problem only to sheepishly say they had used the wrong password. Everybody makes errors. Triple check.
6. Check that your Anti Virus is not hijacking your mail. Turn off email checking temporarily to test.
Good luck. ... Thinkpads_User